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Pathology Misc. 03818f5a

The morphologic features of Neuronal cell deal consist of all EXCEPT

A
Basophilic inclusions
B
Shrinkage of cell body
C
Disappearance of Nissls Substance
D
Pyknosis of the nucleus
High-Yield Explanation
(A) Basophilic inclusions # Acute neuronal injury (red neuron) refers to a spectrum of changes that accompany acute CNS hypoxia/ischemia or infectious and toxic insults that ultimately lead to death of the cell.> Red neurons are evident with hematoxylin and eosin (H&E) preparations at about 12 to 24 hours after an irreversible hypoxic/ ischemic insult.> The morphologic features consist of shrinkage of the cell body, pyknosis of the nucleus, disappearance of the nucleolus, and loss of Nissl substance, with intense eosinophilia of the cytoplasm.> Often, the nucleus assumes the angulated shape of the shrunken perikaryon.> Experimental studies have defined even earlier (4 to 8 hours) structural changes that attend irreversible neuronal injury consisting of small vacuoles within the cell body; these are difficult to detect in human tissue examined post mortem

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