The mesocortical system of dopaminergic neurons is hyperactive and this can be proved by the occurrence of which of the following disease?

Ans. b (Schizophrenia). (Ref. Harrison's medicine 16th ed. 2559)Mesocortical system of dopaminergic neurons is hyperactive in schizophrenia. The dopamine hypothesis of schizophrenia is based on the discovery that agents that diminish dopaminergic activity also reduce the acute symp-toms and signs of psychosis, specifically agitation, anxiety, and hallucination. An increase in the activity of nigrostriatal and mesolimbic systems and decrease in the mesocortical tracts activity innervating the prefrontal cortex is hypothesized, although it is likely that the other neurotransmitters, including serotonin, acetylcholine, glutamine, and GABA, also contribute to the pathophysiology of the illness.