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Pharmacology Endocrinology 0341aa74

True about febuxostat:

A
Anti-gout and Xanthine Oxidase inhibitor
B
Purine inhibitor
C
Dose adjustment required in renal impairment
D
Has uricosuric action
High-Yield Explanation
Ref: Katzung's Pharmacology, 14th ed. pg. 662-63* Febuxostat is a non-purine inhibitor of xanthine oxidase and thereby reduces the formation of xanthine and uric acid and is useful in management of gout.* It is 80% absorbed following oral administration and extensively metabolized in the liver.* All of the drug and its metabolites appear in the urine although less than 5% appears as unchanged drug. Because it is highly metabolized to inactive metabolites, no dosage adjustment is necessary for patients with renal impairment.

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