Autoimmune hemolytic anemia is seen in -
High-Yield Explanation
Clinical features of CLL
Most patients present at ages over 50 with a male predominance
Patients with CLL are often asymptomatic.
When symptoms appear, they are nonspecific and include easy fatigability, weight loss and anorexia.
Other symptoms are : -
Hepatosplenomegaly
Lymphadenopathy
Hypogammaglobulinemia Increased susceptibility to infections.
Autoimmune hemolytic anemia or thrombocytopenia
CLL has a tendency to transform into more aggressive lymphoid neoplams : -
Prolymphocytic leukemia → Characterized by worsening of cytopenia, marked splenomagaly and appearance of prolymphocytes in the peripheral blood.
Richter syndrome → CLL is transformed into diffuse large B-cell lymphoma.