Oral anticoagulants given to pregnant women cause

Contradi's syndrome (Skeletal and facial anomalies optic atrophy, microcephaly, chondrodysplasia punctate. Warfarin given in early pregnancy increases bih defects, specially skeletal abnormality foetal warfarin syndrome - hypoplasia of nose, eye socket hand bones, growth retardation. Given later in pregnancy - it can cause CNS defects, foetal haemorrhage, foetal death and accentuates neonatal hypoprothrombinemia Ref: Katzung 12 th ed.