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Pharmacology Chemotherapy: General Principles 0162b165

Which of the followign drugs require dose adjustment in renal failure?

A
Cefoperazone
B
Doxycycline
C
Streptomycin
D
Rifampicin
High-Yield Explanation
Ans. (C) Streptomycin(Ref: Katzung 10/e p835 KDT 8/e p746)Streptomycin is an aminoglycoside and require dose adjustment in renal failure whereas doxycycline, rifampicin and cefoperazone are secreted in bile and do not require dose adjustment in renal failure.
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