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Medicine G.I.T 014ffc2e

Which is false about Gilbe syndrome

A
Male predominant
B
UGT activity is 10-30 % of normal
C
Histology normal
D
Mild conjugated hyperbilrubinemia
High-Yield Explanation
Gilbe Syndrome is characterized by mild unconjugated hyperbilirubinemia, normal values for standard hepatic biochemical tests, and normal hepatic histology other than a modest increase of lipofuscin pigment in some patients. Serum bilirubin concentrations are most often <51 mmol/L (<3 mg/dL),UGT (UDP-glucuronosyltransferase 1) activity is typically reduced to 10-35% of normal, and bile pigments exhibit a characteristic increase in bilirubin monoglucuronides.Harrison 19e pg:2002

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