XDR-TB is defined as Resistance to -

Ans. is 'd' i.e., Fluoroquinolones plus INH plus rifampicin plus amikacin Treatment of multidrug resistance (MDR) TBo MDR-TB is defined as resistance to at least both INH and rifampicin. Previously it was classified as Category IV under DOTS (DOTS-PLUS).o The treatment is given in two phases, the intestive phase (IP) and the continuation phase (CP). The total duration of treatment for regimen for MDR-TB is 24-27 months, depending on the IP duration.o Treatment regimen comprises :-i) Intensive phase (6-9 months): Six drugs: Kanamycin (Km), levofloxacin (Lvx), ethionamide (Eto), pyrazinamide (Z), ethambutol (E), and cycloserine (Cs).ii) Continuation phase (18 months) : Four drugs: Levofloxaxcin, ethionamide, ethambutol and cycloserineo Total duration of treatment is 24-27 months.Treatment of extensive drug resistance (XDR) TBo XDR-TB is defined as resistance to any fluoroquinolone and at least one of the following three second-line drugs (capreomycin, kanamycin, amikacin), in addition to multidrug resistanceo The Regimen for XDR-TB would be of 24-30 months duration, with 6-12 months Intensive Phase (IP) and 18 months Continuation Phase (CP)o Regimen isi) Intensive phase (6-12 months): Seven drugs : Capreomycin, PAS, moxifloxacin, high dose INH, clofazimine, Linezolid, amoxyclav.ii) Continuation phase (18 months): Six drugs: PAS, moxifloxacin, high dose INH, clofazimine, linezolid, amoxyclav.