Microbiology Immunology 00a43f3c Which is not pyrogenic - A IL-1 B TNF-a C IL-4 D IL-6 High-Yield Explanation Pyrogenic cytokines such as tumor necrosis factor (TNF), interleukin (IL)-1, IL-6, and interferons into the bloodstream in response to exogenous pyrogens. Reff: www.mayoclinic.com