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Pharmacology General pharmacology 008db83c

Which of the following is not conveed into an active metabolite?

A
Lisinopril
B
Fluoxetine
C
Cyclophosphamide
D
Diazepam
High-Yield Explanation
prodrugs are conveed into active metabolites all ACE inhibitors except captopril and lisinopril are prodrugs lisinopril: It is the lysine derivative of enalaprilat: does not require hydrolysis to become an active ACE inhibitor. Fluoxetine has an active demethylated metabolite Diazepam has an active metabolite Desmethyl-diazepam, oxazepam Cyclophosphamide have active metabolite Aldophosphamide, .phosphorarmide mustard, acrolein Ref ;KD Tripathi pharmacology 7th edition (page no; 503,461,22,23)

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