Successful antibiotic penetration of a burn eschar can be achieved with

Mafenide acetate is the antibiotic agent that penetrates burn eschar to reach the interface with patient's ble tissue This agent has the Disadvantage that it is quite painful on any paial thickness areas and it is carbonic anhydrase inhibitor that interferes with renal buffering mechanism Metabolic acidosis can occur Ref: schwaz's principle of surgery 10th edition Pg no: 232